2-bromo-2-nitropropane-1 3-diol là gì
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2-bromo-2-nitropropane-1,3-diol is an anti-microbial substance used primarily in personal care products as a preservative. How can I avoid it? Skin contact with 2-bromo-2-nitropropane-1,3-diol is required for it to cause a rash. Discontinuation of exposure to products containing 2-bromo-2-nitropropane-1,3-diol should result in improvement and/or resolution of your dermatitis. By law, all products made in the U.S. for topical use have the ingredients listed either on the product package or the box that contains it, so check the labeling of your skin care products for this ingredient. If there is not enough information, ask your pharmacist or retailer or contact the company directly. At work, request a Safety Data Sheet (SDS) to help identify potential sources of exposure. It should be noted that some individuals who are allergic to 2-bromo-2-nitropropane-1,3-diol may also be sensitive to formaldehyde or other formaldehyde-releasing preservatives. Discuss with your health care provider which potentially cross-reacting chemicals you should avoid. 1,3-Propanediol-2-Bromo-2-Nitro; 2-Bromo-2-nitro-1,3-propanediol; b-Bromo-b-nitrotrimethyleneglycol; Bronopol; Bronosol; Lexgard bronopol; Onyxide 500; 2-nitro-2-bromo-1,3-propanediol; bronocot; bronidiol; myacide as; Bromo-2-nitro-1,3-propanediol; Bromo-2-nitropropane-1,3-diol; 2-Bronopol. Uses:This compound is used as a bactericide, in seed treatment for control of Xanthomonas malvacearum, as a foliar spray for control of a wide range of plant-pathogenic bacteria (especially Erwinia amylovora), in antiseptics and as a preservative in cosmetics, cooling fluids, hand & face creams, shampoos, hair dressings, mascaras, cleansing lotions, milk sampling, paints, textiles, humidifiers, pharmaceutical products, washing detergents Use restrictions (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (high), Ecotoxicology (low), Irritation (skin, eyes, or lungs) (high), Occupational hazards (high), and Contamination concerns (high) SYNONYMS ● 1,3-PROPANEDIOL, 2-BROMO-2-NITRO- ● 1,3PROPANEDIOL, 2BROMO2NITRO ● 2-BROMO-2-NITRO- 1,3-PROPANEDIOL ● 2-BROMO-2-NITROPROPANE-1,3-DIOL ● 2-BROMO-2-NITROPROPANE-1,3-DIOL (FORMALDEHYDE RELEASER) ● BRONOPOL Restricted - Unaccpetable The score of this ingredient can vary from Restricted to Unacceptable based on the method of product consumption. For instance, when used in aerosol-based products, this ingredient may pose a risk to respiratory health, leading to a higher score Click here for more information about ingredient scores 2-Bromo-2-nitropropane-1,3-diol is an antimicrobial preservative that works by forming formaldehyde in cosmetic products. People exposed to such formaldehyde-releasing ingredients may develop a formaldehyde allergy or an allergy to the ingredient itself. In the U.S. approximately 20% of cosmetics and personal care products contain a formaldehyde-releaser and the frequency of contact allergy to these ingredients is much higher among Americans compared to studies in Europe. Common concernsSee how this product scores for common concerns.
Ingredient concerns
hair styling aide27 products liquid hand soap13 products baby wipes10 products mask6 products hand sanitizer4 products makeup remover4 products conditioner3 products hair treatment/serum3 products body wash/cleanser3 products body cleansing wipes2 products shampoo2 products serums & essences2 products anti-aging2 products hair color and bleaching2 products moisturizer2 products hair spray2 products beard oil2 products facial moisturizer/treatment2 products around-eye cream1 products eyelash glue1 products antiperspirant/deodorant1 products makeup removing wipes1 products facial cleanser1 products sunless tanning1 products CONCERN REFERENCE Known human skin toxicant or allergenOpen scientific literature Human any toxicant or allergen - strong evidenceOpen scientific literature Human skin toxicant or allergen - strong evidenceEWG Assessment of Open Scientific Literature Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap CONCERN REFERENCE Known human lung and skin toxicantCPS&Q - Classification & Labelling Limited evidence of gastrointestinal or liver toxicityScorecard.org Toxicity Information One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Toxic Release Inventory PBTs Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List CONCERN REFERENCE Classified as lung and skin irritantCPS&Q - Classification & Labelling CONCERN REFERENCE Allowed workplace exposures restricted to low dosesCPS&Q - Classification & Labelling CONCERN REFERENCE Persistent or bioaccumulative and moderate to high toxicity concern in humansOpen scientific literature Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List Not suspected to be persistentEnvironment Canada Domestic Substance List CONCERN REFERENCE Cancer - limited evidenceOpen scientific literature CONCERN REFERENCE Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsCosmetic Ingredient Review Assessments CONCERN REFERENCE Wildlife and environmental toxicityCPS&Q - Classification & Labelling Suspected to be an environmental toxinEnvironment Canada Domestic Substance List CONCERN REFERENCE Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments 165 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed
Understanding scoresCosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern. Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating. HOW WE DETERMINE SCORES Hazard scoreThe Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.
Data availabilityThe Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature. |
